UK Biobank Pharma Proteomics Project (UKB-PPP)

Description

The UKB-PPP is a collaboration between the UK Biobank (UKB) and thirteen biopharmaceutical companies characterising the plasma proteomic profiles of 54,219 UKB participants. As part of a collaborative analysis across the thirteen UKB-PPP partners, we conducted comprehensive protein quantitative trait loci (pQTL) mapping of 2,923 proteins that identifies 14,287 primary genetic associations, of which 85% are newly discovered, in addition to ancestry-specific pQTL mapping in non-Europeans. We identify independent secondary associations in 87% of cis and 30% of trans loci, expanding the catalogue of genetic instruments for downstream analyses.

Update Frequency

Never

License

[CC BY]

Documentation

https://www.synapse.org/#!Synapse:syn51364943/

Managed By

Sage Bionetworks

See all datasets managed by Sage Bionetworks.

Contact

matthias.arnold@helmholtz-munich.de

How to Cite

UK Biobank Pharma Proteomics Project (UKB-PPP) was accessed on DATE from https://registry.opendata.aws/ukbppp. Sun, B.B., Chiou, J., Traylor, M. et al. Plasma proteomic associations with genetics and health in the UK Biobank. Nature 622, 329–338 (2023). https://doi.org/10.1038/s41586-023-06592-6

Usage Examples

Publications

• Plasma proteomic associations with genetics and health in the UK Biobank by Sun B, Chiou J, Traylor M, Benner C, Hsu Y, Richardson T, et al